Table 4.
Statistically significant GO biological processes (BP) derived from ubiquitinated proteins in human pituitary adenomas.
| ID | Biological process | GeneRatio | BgRatio | P-value | P.adjust | Q-value | GeneID | Count |
|---|---|---|---|---|---|---|---|---|
| GO:0097237 | Cellular response to toxic substance | 5/30 | 235/18493 | 3.49E-05 | 1.66E-02 | 1.27E-02 | ALB/RPS3/HBA1/HBA2/PDCD10 | 5 |
| GO:0042542 | Response to hydrogen peroxide | 4/30 | 141/18493 | 7.61E-05 | 1.66E-02 | 1.27E-02 | RPS3/HBA1/HBA2/PDCD10 | 4 |
| GO:0045739 | Positive regulation of DNA repair | 3/30 | 61/18493 | 1.30E-04 | 1.66E-02 | 1.27E-02 | H2AFX/RPS3/UBE2N | 3 |
| GO:0042983 | Amyloid precursor protein biosynthetic process | 2/30 | 11/18493 | 1.39E-04 | 1.66E-02 | 1.27E-02 | ITM2C/ITM2B | 2 |
| GO:0042984 | Regulation of amyloid precursor protein biosynthetic process | 2/30 | 11/18493 | 1.39E-04 | 1.66E-02 | 1.27E-02 | ITM2C/ITM2B | 2 |
| GO:0046677 | Response to antibiotic | 5/30 | 323/18493 | 1.57E-04 | 1.66E-02 | 1.27E-02 | RPS3/HBA1/PRL/HBA2/PDCD10 | 5 |
| GO:0010561 | Negative regulation of glycoprotein biosynthetic process | 2/30 | 12/18493 | 1.66E-04 | 1.66E-02 | 1.27E-02 | ITM2C/ITM2B | 2 |
| GO:0031581 | Hemidesmosome assembly | 2/30 | 12/18493 | 1.66E-04 | 1.66E-02 | 1.27E-02 | LAMC2/PLEC | 2 |
| GO:0015671 | Oxygen transport | 2/30 | 15/18493 | 2.64E-04 | 2.11E-02 | 1.62E-02 | HBA1/HBA2 | 2 |
| GO:1903019 | Negative regulation of glycoprotein metabolic process | 2/30 | 15/18493 | 2.64E-04 | 2.11E-02 | 1.62E-02 | ITM2C/ITM2B | 2 |
| GO:0015893 | Drug transport | 4/30 | 217/18493 | 3.98E-04 | 2.56E-02 | 1.96E-02 | HBA1/HBA2/SLC32A1/TMEM30A | 4 |
| GO:0015669 | Gas transport | 2/30 | 19/18493 | 4.28E-04 | 2.56E-02 | 1.96E-02 | HBA1/HBA2 | 2 |
| GO:2001022 | Positive regulation of response to DNA damage stimulus | 3/30 | 92/18493 | 4.39E-04 | 2.56E-02 | 1.96E-02 | H2AFX/RPS3/UBE2N | 3 |
| GO:0000302 | Response to reactive oxygen species | 4/30 | 224/18493 | 4.48E-04 | 2.56E-02 | 1.96E-02 | RPS3/HBA1/HBA2/PDCD10 | 4 |
| GO:0098869 | Cellular oxidant detoxification | 3/30 | 101/18493 | 5.77E-04 | 3.08E-02 | 2.36E-02 | ALB/HBA1/HBA2 | 3 |
| GO:1990748 | Cellular detoxification | 3/30 | 105/18493 | 6.46E-04 | 3.23E-02 | 2.47E-02 | ALB/HBA1/HBA2 | 3 |
| GO:0006282 | Regulation of DNA repair | 3/30 | 115/18493 | 8.41E-04 | 3.96E-02 | 3.03E-02 | H2AFX/RPS3/UBE2N | 3 |
| GO:0031112 | Positive regulation of microtubule polymerization or depolymerization | 2/30 | 29/18493 | 1.01E-03 | 4.30E-02 | 3.30E-02 | RPS3/STMN2 | 2 |
| GO:0098754 | Detoxification | 3/30 | 123/18493 | 1.02E-03 | 4.30E-02 | 3.30E-02 | ALB/HBA1/HBA2 | 3 |
| GO:0042744 | Hydrogen peroxide catabolic process | 2/30 | 32/18493 | 1.22E-03 | 4.77E-02 | 3.66E-02 | HBA1/HBA2 | 2 |
| GO:0051291 | Protein heterooligomerization | 3/30 | 132/18493 | 1.25E-03 | 4.77E-02 | 3.66E-02 | IDE/HBA1/HBA2 | 3 |
GeneRatio = The ratio of the number of genes enriched by the BP to the total number of genes enriched. BgRatio = The ratio of the number of genes contained in the BP to the number of genes in the BP database.