Table 2.
Changes in apparent clearance, total daily dose and serum concentration from pre-pregnancy status.
| Trimester | Number of samples | Apparent clearance (l/day) | Total daily dose (mg) | Serum concentration (mg/l) | Serum concentration adjusted for dose (mg/l) |
|---|---|---|---|---|---|
| 1 | 51 | ↑71.08 (16.33,125.83) p = 0.011 |
↑97.73 (176.99,372.46) p = 0.486 |
↓5.76 (2.78,8.75) p < 0.001 |
↓6.37 (3.60.9.13) p < 0.001 |
| 2 | 88 | ↑69.54 (15.3,123.79) p = 0.012 |
↑487.35 (171.16,803.54) p = 0.003 |
↓3.39 (0.17,6.60) p = 0.039 |
↓6.39 (3.13,9.66) p < 0.001 |
| 3 | 59 | ↑76.07 (12.74,139.41) p = 0.019 |
↑719.05 (326.95,1111.16) p < 0.001 |
↓4.41 (1.11,7.71) p = 0.009 |
↓8.84 (5.80,11.88) p < 0.001 |
| Post-partum | 16 | ↓58.68 (2.88,114.48) p = 0.039 |
↑651.84 (116.62,1187.06) p = 0.017 |
↑10.17 (1.61,18.73) p = 0.02 |
↑6.15 (−0.055,12.36) p = 0.052 |
Values are presented as mean change (95% CI), p value; ↑ increased; ↓ decreased.