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. 2019 May 17;9(2):2045894019848659. doi: 10.1177/2045894019848659

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Effects of PTB and pirfenidone treatment on hemodynamics and body weight. (a) At the end of the study seven weeks after PTB or sham operation, RV systolic pressure (RVSP) was increased and (b) RV cardiac index (CI) reduced in the PTB rats. (c) RV dilatation was evident by an increase in RV end-diastolic volume (EDV) and end-systolic volume (ESV) (open dots). (d) Six weeks of pirfenidone treatment lowered body weight compared with untreated rats. Representative short-axis MRI images of (e) a sham rat and (f) a PTB rat with RV hypertrophy and dilatation. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.