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. 2019 May 17;9(2):2045894019848659. doi: 10.1177/2045894019848659

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 3. — Effects of PTB and pirfenidone on interstitial fibrosis. At the end of the study, volume fraction of fibrosis was increased in (a) the RV, (b) the septum, and (c) the LV of PTB rats compared with sham. (d–f) Likewise, absolute volume of fibrosis was increased. Pirfenidone-treated PTB had (e) lower absolute volumes of fibrosis in the septum and (f) a trend towards a lower volume in the LV due to the lower volumes of the septum and the LV in the PTB + pirf rats compared with PTB control rats. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.