Table 1.
Sham (n = 11) | PTB (n = 11) | PTB + pirf (n = 10) | |
---|---|---|---|
Anatomical data | |||
RV weight (g) | 0.22 ± 0.02 | 0.49 ± 0.07* | 0.47 ± 0.4 |
LV + S weight (g) | 0.86 ± 0.07 | 0.87 ± 0.10 | 0.74 ± 0.09† |
RV/LV + S | 0.26 ± 0.02 | 0.57 ± 0.09* | 0.63 ± 0.04 |
RV/tibia length (mg/mm) | 5.4 ± 0.4 | 12.0 ± 1.6 | 12.5 ± 2.8 |
LV + S/tibia length (mg/mm) | 21.0 ± 1.2 | 21.3 ± 2.3 | 18.6 ± 2.0† |
Hemodynamic measures | |||
Heart rate (bpm) | 329 ± 19 | 279 ± 30* | 276 ± 25 |
RV stroke volume (mL) | 0.40 ± 0.05 | 0.23 ± 0.03* | 0.20 ± 0.03 |
RV EF (%) | 74 ± 4 | 51 ± 5* | 47 ± 8 |
RV EDP (mmHg) | 4.2 ± 3.1 | 8.9 ± 5.9 | 8.3 ± 4.6 |
RV filling pressure (mmHg) | 1.6 ± 0.4 | 5.3 ± 1.8* | 3.5 ± 1.0† |
RV dP/dt max (mmHg/s) | 1231 ± 261 | 4042 ± 816* | 3408 ± 579 |
RV dP/dt min (mmHg/s) | −1117 ± 314 | −3087 ± 452* | −2709 ± 585 |
Ea (mmHg/mL) | 70 ± 19 | 458 ± 85* | 463 ± 99 |
Ees (mmHg/mL) | 108 ± 35 | 277 ± 95* | 253 ± 77 |
Ees/Ea | 1.56 ± 0.55 | 0.47 ± 0.17* | 0.53 ± 0.15 |
Eed (mmHg/mL) | 2.7 ± 1.2 | 19.2 ± 13.0§ | 15.8 ± 12.1 |
RV PRSW (mmHg) | 22 ± 9 | 50 ± 22§ | 39 ± 13 |
TAPSE (mm) | 2.5 ± 0.1 | 1.6 ± 0.3* | 1.7 ± 0.2 |
LV EDV (mL) | 0.64 ± 0.06 | 0.42 ± 0.05* | 0.40 ± 0.06 |
LV ESV (mL) | 0.16 ± 0.03 | 0.13 ± 0.04 | 0.13 ± 0.03 |
LV EF (%) | 75 ± 5 | 68 ± 6‡ | 66 ± 6 |
MAP (mmHg) | 109 ± 11 | 113 ± 8 | 117 ± 12 |
Data are presented as mean ± SD or n.
P < 0.001 vs. sham.
P < 0.01 vs. PTB.
P < 0.05 vs. sham.
P < 0.01 vs. sham.
RV, right ventricle; LV + S, left ventricle plus septum; LV, left ventricle; EDP, end-diastolic pressure; RV dP/dt, first derivative of right ventricular systolic pressure; Ea, arterial elastance; Ees, end-systolic elastance; Eed, end-diastolic elastance; PRSW, preload recruitable stroke work; TAPSE, tricuspid annular plane systolic excursion; EDV, end-diastolic volume; ESV, end-systolic volume; EF, ejection fraction; MAP, mean arterial pressure.