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. 2019 May 28;7:140. doi: 10.1186/s40425-019-0622-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Therapeutic targeting of tumor-associated macrophages in cancer. TAM are a promising target for the immunotherapy of cancer. Several approaches to reduce TAM or functionally modify TAM include blocking monocyte recruitment to the tumor, deletion through antigen-specific targeting, reprogramming of TAM to M1 macrophages and inhibiting the activation of TAM