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. 2019 May 22;10:522. doi: 10.3389/fphar.2019.00522

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Copyright © 2019 Xiong, Ding, Chen, Wang, Liu, Qin, Zhou, Zhang, Huang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of emodin on the SHP-BSEP signaling pathway in ANIT-treated rats. The mRNA levels of FXR and BSEP were measured by real-time PCR (A). The protein levels of FXR1, FXR2, and BSEP were detected by Western blotting (B,C). Data were expressed as the mean ± SD. n = 3. (^#P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.05 compared to the UDCA group; ^Δp < 0.05 compared to the DXM group, as determined by Student’s t-test).

Inline graphic — Effect of emodin on the SHP-BSEP signaling pathway in ANIT-treated rats. The mRNA levels of FXR and BSEP were measured by real-time PCR (A). The protein levels of FXR1, FXR2, and BSEP were detected by Western blotting (B,C). Data were expressed as the mean ± SD. n = 3. (^#P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.05 compared to the UDCA group; ^Δp < 0.05 compared to the DXM group, as determined by Student’s t-test).