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. 2019 May 22;10:522. doi: 10.3389/fphar.2019.00522

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Copyright © 2019 Xiong, Ding, Chen, Wang, Liu, Qin, Zhou, Zhang, Huang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(1) Effect of emodin on pathological manifestation of hepatic tissue by HE staining at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DXM group; F: model group; G: control group). (2) Effect of emodin on BSEP expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DEX group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test). (3) Effect of emodin on FXR1 expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DXM group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test). (4) Effect of emodin on FXR2 expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DEX group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test).

Inline graphic — (1) Effect of emodin on pathological manifestation of hepatic tissue by HE staining at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DXM group; F: model group; G: control group). (2) Effect of emodin on BSEP expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DEX group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test). (3) Effect of emodin on FXR1 expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DXM group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test). (4) Effect of emodin on FXR2 expression was examined with IHC at 400× magnification (A: emodin 20 mg/kg group; B: emodin 40 mg/kg group; C: emodin 80 mg/kg group; D: UDCA group; E: DEX group; F: model group; G: control group. Values are the means ± SD. n = 3, ^##P < 0.01 compared to the control group, ^∗∗P < 0.01 compared to the model group; p < 0.01 compared to the UDCA group; ^ΔΔp < 0.01 compared to the DXM group, as determined by Student’s t-test).