(A1–A3) The crystal deposit scores of different groups(Kruskal-Wallis test). (A1) 0.01% K-CA+0.05% NaOx vs. 0.05% NaOx: p=0.124, 0.01% K-HCA+0.05% NaOx vs. 0.05% NaOx: p=0.026; (A2) 0.1% K-CA+0.05% NaOx vs. 0.05% NaOx: p=0.008, 0.1% K-HCA+0.05% NaOx vs. 0.05% NaOx: p=0.005; (A3) 1% K-CA+0.05% NaOx vs. 0.05% NaOx: p=0.006, 1% K-HCA+0.05% NaOx vs. 0.05%NaOx: p=0.002. (B1–B3) The life span curves of different groups (Log-rank test). (B1) 0.01% K-CA+0.05% NaOx vs. control: p=0.3683, 0.01% K-HCA+0.05% NaOx vs. control: p=0.4927; (B2) 0.1%K-CA+0.05% NaOx vs. control: p=0.6217, 0.1% K-HCA+0.05% NaOx vs. control:p=0.6173; (B3) 1% K-CA+0.05% NaOx vs. control: p=0.7632; 1% K-HCA+0.05% NaOx vs. control: p=0.8436.