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. 2019 May 22;6:113. doi: 10.3389/fmed.2019.00113

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Copyright © 2019 Graves, CelliMarchett, van Zyl, Tang, Vilain, van der Westhuizen and Bowden.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency of TIM3 expression on CD4+ and CD8+ T cells. (A) The mean percentage of CD4+ T cells expressing TIM3 in non-responders responders to pembrolizumab (B) The mean percentage of CD8+ T cells expressing TIM3 in non-responders responders to pembrolizumab (C) Boxplot of mean frequency of TIM3 on CD4+ and CD8+ T cells per patient per cycle. *p < 0.05.