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. 2019 May 22;10:566. doi: 10.3389/fphar.2019.00566

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Copyright © 2019 Shao, Gong, Qi, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PF improved clinical symptoms and alleviated inflammation. (A) The chemical structure of paeoniflorin. (B) Blood glucose levels. (C) Kidney /body weight. (D) Urine albumin excretion. Data were detected and are presented as the mean ± SD of at least three independent experiments. n = 12 in each group. NS: not significant; ^∗p < 0.05 and ^∗∗p < 0.01 vs. WT; ^#p < 0.05 and ^##p<0.01 vs. WT+STZ. (E–H) Expression of iNOS, TNF-α, IL-1β, and MCP-1 in renal tissue. The results are represented as the mean ± SD of at least three repeated experiments. ^∗p < 0.05 and ^∗∗p < 0.01 vs. WT; ^#p < 0.05 and ^##p < 0.01 vs. WT+STZ; NS, not significant.