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. 2019 May 22;10:566. doi: 10.3389/fphar.2019.00566

FIGURE 3.

FIGURE 3

Effects of PF on the expression of TLR4 and downstream signaling pathway molecules in mice from different groups. (A,B) Renal tissue lysates were analyzed by Western blotting to measure the expression of TLR4 and molecules in the downstream signaling pathway, including MyD88, p-IRAK1, Trif, p-IRF3, NF-κB p-p65, and NF-κB p65. All data are expressed as the mean ± SD from at least three independent experiments. ∗p < 0.05 and ∗∗p < 0.01 vs. WT; #p < 0.05 and ##p < 0.01 vs. WT+STZ; NS, not significant. Lanes: 1, WT; 2, WT+STZ; 3, WT+STZ+PF 25 mg/kg; 4, WT+STZ+PF 50 mg/kg; 5, WT+STZ+PF 100 mg/kg; 6, TLR4-/-; and 7, TLR4-/-+STZ.