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. 2019 May 22;10:566. doi: 10.3389/fphar.2019.00566

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Copyright © 2019 Shao, Gong, Qi, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular experimental conditions. The optimal concentration and stimulation time of D-glucose and the optimal PF concentration were determined first. (A) Identification of BMDMs. (B) Effects of different high concentrations of glucose on TLR4 expression and BMDM activation. (C) Effects of high-glucose stimulation on TLR4 and BMDM activation at different time points. (D) Effects of various PF concentrations on TLR4 expression and BMDM activation. (E) Cell viability detected using a CCK-8-based assay. (F) Cell migration detected by the Transwell method. Values are expressed as the mean ± SD of at least three independent experiments. NS: not significant; ^∗P < 0.05 and ^∗∗P < 0.01 vs. the LG group; ^#p < 0.05 and ^##p < 0.01 vs. the HG group; ^▲P < 0.05, ^▲▲P < 0.01 vs. the TLR4-/-+HG group.