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. 2019 May 22;10:566. doi: 10.3389/fphar.2019.00566

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Copyright © 2019 Shao, Gong, Qi, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PF could suppress iNOS and inflammatory factor levels in HG-induced macrophages. (A–D) Effects of PF treatment and TLR4 deficiency on HG-stimulated iNOS and inflammatory cytokine expression. BMDMs were treated with HG stimulation for 24 h, and mRNA levels were detected by qRT-PCR. (E–G) Detection of the levels of TNF-α, IL-1β, and MCP-1 secreted by HG-stimulated BMDMs. Conditioned medium was removed, and ELISAs were used to detect soluble TNF-α, IL-1β and MCP-1 peptides. ^∗P < 0.05 and ^∗∗P < 0.01 vs. the LG group; ^##P < 0.01 vs. the HG group; ^▲▲P < 0.01 vs. the TLR4-/-+HG group; NS: not significant.