TABLE 2.
Echocardiographic analysis of cardiac function in global mPges-1 KO mice
| Days after Coronary Ligation |
||||||
|---|---|---|---|---|---|---|
| 0 |
7 |
28 |
||||
| gWT (n = 4) | gKO (n = 4) | gWT (n = 8) | gKO (n = 7) | gWT (n = 14) | gKO (n = 12) | |
| Body weight (g) | 28.73 ± 1.37 | 26.38 ± 1.25 | 24.28 ± 3.21 | 25.97 ± 3.58 | 25.13 ± .08 | 26.90 ± 2.29 |
| LV mass (mg) | 92.78 ± 9.89 | 82.71 ± 1058 | 90.88 ± 15.79 | 91.19 ± 16.42 | 86.35 ± 16.32 | 84.05 ± 19.79 |
| LV mass/BW (mg/g) | 3.24 ± 0.40 | 3.13 ± 0.30 | 3.76 ± 0.53 | 3.51 ± 0.45 | 3.49 ± 0.82 | 3.11 ± 0.63 |
| Heart rate (bpm) | 454.00 ± 49.77 | 401.75 ± 21.28 | 471.63 ± 62.80 | 481.43 ± 58.20 | 456.36 ± 64.58 | 460.17 ± 50.38 |
| Cardiac output (ml/min) | 23.91 ± 4.61 | 16.84 ± 0.82 | 12.70 ± 5.43 | 15.87 ± 4.98 | 15.34 ± 3.46 | 15.54 ± 2.33 |
| Stroke volume (μl) | 53.69 ± 14.46 | 41.97 ± 2.56 | 28.06 ± 13.25 | 33.38 ± 10.70 | 34.01 ± 7.78 | 34.26 ± 6.76 |
| Ejection fraction (%) | 59.91 ± 5.83 | 57.02 ± 2.49 | 33.14 ± 19.57 | 37.48 ± 23.40 | 40.07 ± 16.68 | 49.96 ± 19.42 |
| Fractional shortness (%) | 28.40 ± 2.48 | 28.60 ± 3.16 | 19.07 ± 10.14 | 20.18 ± 12.49 | 22.63 ± 10.52 | 28.27 ± 12.79 |
| LV internal diameter, end systole (mm) | 2.92 ± 0.43 | 2.83 ± 1.89 | 3.82 ± 1.29 | 4.06 ± 1.82 | 3.45 ± 1.51 | 3.08 ± 1.72 |
| LV internal diameter, end diastole (mm) | 4.07 ± 0.50 | 3.97 ± 0.11 | 4.63 ± 1.04 | 4.89 ± 1.52 | 4.32 ± 1.22 | 4.08 ± 1.40 |
BW, body weight; gKO, global mPges-1 KO; gWT, global mPges-1 WT; LV, left ventricular.