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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Invest Dermatol. 2019 Jun;139(6):1208–1213.e1. doi: 10.1016/j.jid.2019.03.1134

Figure 2. A circulating factor promotes scar formation in aged mice.

Figure 2.

. (a) Isochronic aged:aged parabiosis led to significant wound closure, while isochronic young:young parabiosis did not, as photographed. Within the heterochronic parabiosis pairs, the aged parabiont did not close its ear hole and adopted the young parabiont phenotype. (b) Ear hole measurements of individual parabionts within each pair. n = 5. ***p < 0.001, comparing aged:aged with young:young or either parabiont of young:aged. Aged:aged parabionts had significant wound closure compared to young:young or young:aged parabionts.