Comparison 1. Ibuprofen 400 mg + high dose codeine versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with ≥ 50% pain relief	4	443	Risk Ratio (M‐H, Fixed, 95% CI)	4.09 [2.82, 5.93]
2 Participants with any adverse event	4	443	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.84, 1.66]