Adverse events
Study ID	Treatment	Any	Serious	Withdrawals
Cooper 1982	(1) Ibuprofen 400 mg + codeine 60 mg, n = 41 (2) Ibuprofen 400 mg, n = 38 (3) Aspirin 650 mg + codeine 60 mg, n = 45 (4) Aspirin 650 mg, n = 38 (5) Codeine sulphate 60 mg, n = 41 (6) Placebo, n = 46	(1) 18/41 (2) 11/38 (5) 11/38 (6) 5/46 Events were mostly drowsiness and nausea	None	None
Daniels 2011	(1) Ibuprofen 400 mg + codeine 25.6 mg, n = 169 (2) Paracetamol 1000 mg + codeine 30 mg, n = 113 (3) Ibuprofen 200 mg + paracetamol 500 mg, n = 173 (4) Ibuprofen 400 mg + paracetamol 1000 mg, n = 168 (5) Placebo, n = 55	(1) 59/169 (5) 21/55 Events were nausea, vomiting, headache, dizziness, alveolar osteitis, body temperature increased	None	None
Frame 1986	(1) Ibuprofen 200 mg + codeine 15 mg, n = 32 (2) Ibuprofen 400 mg + codeine 30 mg, n = 26 (3) Ibuprofen 800 mg + codeine 60 mg, n = 26 (4) Aspirin 600 mg, n = 25 (5) Placebo, n = 26	(1) 2/32 (2) 0/26 (3) 9/26 (4) 3/33 (5) 5/26 Events were nausea, dyspepsia, tiredness, faintness/shakiness, headaches, photophobia, muscle ache, and sore mouth	None	None
McQuay 1989	(1) Ibuprofen 400 mg + codeine 20 mg, n = 24 (2) Ibuprofen 400 mg, n = 23	No single dose data After 2 days, multiple doses (1) 3/24 (2) 5/23	None	None
Petersen 1993	(1) Ibuprofen 400 mg + codeine 60 mg, n = 29 (2) Ibuprofen 400 mg, n = 31	No single dose data After 2 doses (1) 14/29 (2) 6/31	None	None
Sunshine 1987	(1) Ibuprofen 200 mg + codeine 30 mg, n = 40 (2) Ibuprofen 400 mg + codeine 60 mg, n = 40 (3) Ibuprofen 400 mg, n = 38 (4) Codeine sulphate 60 mg, n = 37 (5) Placebo, n = 40	(1) 1/40 (2) 1/40 (3) 0/38 (4) 0/37 (5) 0/40 Events were drowsiness (moderate) and numbness of legs (mild)	None	None