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. 2018 Mar 22;97(Suppl 1):S48–S113. doi: 10.1055/s-0043-121596

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Abb. 5 — Immunhistochemischer Nachweis der p16INK4A Proteinexpression in einzelnen Zellen von gesundem Plattenepithel (links oben). In der Regel fehlt p16INK4A in HPV-negativen Plattenepithelkarzinomen des Oropharynx (links unten). p16INK4A liegt jedoch bei HPV-assoziierten OSCC (unten Mitte) und Dysplasien (oben rechts) stark überexprimiert vor. Einzelne OSCC zeigen stellenweise eine schwache Expression von p16INK4A (rechts unten), die im Rahmen der HPV-Diagnostik jedoch nicht als positiv zu bewerten ist.