Figure 4.

Transcriptome analysis of cervical epithelium exposed to  HIV‐1 and NG identified upregulated cellular genes. Heat map showing transcriptome analysis of epithelial layer of the cervix using next‐generation sequencing of tissue epithelium exposed to (A) HIV‐1 (n = 6) and (B)  NG  (n = 6). NG depicts Neisseria numbered 1‐6, and HIV‐1 is also numbered 1‐6. C depicts tissues exposed to control supernatant and numbered as 1‐6. Figure shows only the six tissues which were subjected to transcriptome analysis and genes which were found to be upregulated. Venn diagram showing (C) common genes CXCL10 and IL8 expressed by NG and HIV‐1 exposure on the cervical epithelium. The expression of the genes in (A) NG‐exposed and (B) HIV‐1‐exposed ecto‐cervical epithelia was at least 2‐fold difference with false discovery rate (FDR) <0.05 compared to the controls