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. 2019 Apr 11;81(6):e13111. doi: 10.1111/aji.13111

Figure 5.

Figure 5

Effect of IL‐1β on the transmission of HIV‐1 across cervical mucosa. A, IL8 (200 ng/mL) and CXCL10 (1000 pg/mL) at concentrations present in the 24‐h NGIS increased the transmission of HIV‐1 across cervical mucosa in the organ culture. B, Inhibitory drugs erythromycin (5 μg/mL) against IL‐8 and catechin hydrate (20 ng/mL) against CXCL10 decreased the transmission of HIV‐1 across the mucosa. C, IL‐1β (2500 pg/mL) in concentration present in the 24‐h NGIS increases the transmission of HIV‐1 across cervical mucosa in the organ culture. D, Addition of IL‐1β inhibitor (10 μg/mL trans‐chalcone) decreased the transmission of HIV‐1. E, Addition of the IL‐1β (2500 pg/mL) on the cervical tissues increased the CXCL10 and IL8 in the tissues at the mRNA level. F, IL‐1β as well as a combination of CXCL10 and IL8 increased the HIV‐1 transcription in the tissues compared to media exposed control. G, Monoclonal antibodies against IL‐1β (10 μg/mL) in the NGIS along with HIV‐1 decreased transmission compared to NGIS and HIV‐1 alone. P ≤ 0.05 was considered as significant, and either parametric t tests or t test unequal variance was used to calculate the P values