Table 3.
Results of RMANOVA for ABGs.
| Variable | Time | Cobinamide group (n = 5) | Control group (n = 6) | Difference between cobinamide and control group (95% CI) |
|---|---|---|---|---|
| pH | Baseline | 7.5 ± 0.02 (5) | 7.5 ± 0.07 (2) | 0.02 (−0.05, 0.10) |
| Baseline 2 | 7.4 ± 0.04 (5) | 7.4 ± 0.03 (6) | 0.03 (−0.02, 0.08) | |
| Treatment | 7.5 (1) | 7.3 ±0.04 (4) | – | |
| 5 min | 7.4 ±0.03 (4) | (0) | – | |
| 10 min | 7.5 ± 0.03 (3) | 7.2 ± 0.07 (4) | −0.24 (−0.30, −0.17) | |
| 20 min | 7.5 ± 0.02 (5) | 7.1 (1) | – | |
| 30 min | 7.5 ± 0.04 (5) | (0) | – | |
| 40 min | 7.4 ± 0.02 (5) | (0) | – | |
| 50 min | 7.4 ± 0.02 (5) | (0) | – | |
| 60 min | 7.5 ± 0.01 (5) | (0) | – | |
| pO2 | Baseline | 258.0 ± 71.3 (5) | 215.5 ± 9.2 (2) | −42.5 (−95.2, 10.2) |
| Baseline 2 | 67.6 ± 14.2 (5) | 91.3 ± 20.1 (6) | 23.7 (−14.5, 61.8) | |
| Treatment | 51.6 ± 13.7 (5) | 33.7 ± 8.6 (6) | −17.9 (−56.1, 20.3) | |
| 5 min | 53.3 ± 7.5 (4) | (0) | – | |
| 10 min | 57.0 ± 11.3 (3) | 37.9 ± 25.4 (4) | −19.2 (−67.3, 29.0) | |
| 20 min | 55.8 ± 7.7 (5) | 27.6 (1) | – | |
| 30 min | 58.8 ± 6.1 (5) | (0) | – | |
| 40 min | 64.8 ± 13.0 (5) | (0) | – | |
| 50 min | 65.4 ± 15.0 (5) | (0) | – | |
| 60 min | 70.6 ± 17.1 (5) | (0) | – | |
| pCO2 | Baseline | 33.4 ± 4.3 (5) | 32.0 ± 3.2 (2) | −1.5 (−14.8, 11.9) |
| Baseline 2 | 44.1 ± 2.5 (5) | 44.2 ± 3.1 (6) | 0.2 (−9.5, 9.8) | |
| Treatment | 29.2 (1) | 64.4 ± 7.0 (4) | – | |
| 5 min | 38.9 ± 5.2 (4) | 71.8 ± 9.3 (4) | 32.9 (21.6, 44.2) | |
| 10 min | 37.6 ± 5.7 (3) | 63.1 ± 28.4 (2) | 25.5 (10.9, 40.0) | |
| 20 min | 40.3 ± 6.0 (5) | (0) | – | |
| 30 min | 37.1 ± 4.3 (5) | (0) | – | |
| 40 min | 39.8 ± 3.6 (5) | (0) | – | |
| 50 min | 40.3 ± 4.6 (5) | (0) | – | |
| 60 min | 38.1 ± 3.2 (5) | (0) | – | |
| HCO3 | Baseline | 26.8 ± 2.9 (5) | 28.0 ± 1.5 (6) | 1.2 (−1.8, 4.1) |
| Baseline 2 | 27.5 ± 1.9 (5) | 30.1 ± 0.7 (2) | 2.6 (−1.5, 6.7) | |
| Treatment | 24.5 (1) | 26.2 ± 1.7 (4) | – | |
| 5 min | 26.7 ± 2.2 (4) | (0) | – | |
| 10 min | 26.9 ± 2.7 (3) | 22.7 ± 3.1 (4) | −4.1 (−7.9, −0.4) | |
| 20 min | 26.3 ± 1.9 (5) | 18.3 (1) | – | |
| 30 min | 27.0 ± 2.5 (5) | (0) | – | |
| 40 min | 27.2 ± 2.0 (5) | (0) | – | |
| 50 min | 27.8 ± 2.9 (5) | (0) | – | |
| 60 min | 27.2 ± 2.1 (5) | (0) | – | |
| SO2 | Baseline | 100.0 ± 0.0 (5) | 100.0 ± 0.0 (2) | 0.0 (−4.8, 4.8) |
| Baseline 2 | 92.2 ± 3.7 (5) | 93.5 ± 3.5 (2) | 1.3 (−3.5, 6.1) | |
| Treatment | 88.0 (1) | (0) | – | |
| 5 min | 87.5 ± 3.9 (4) | (0) | – | |
| 10 min | 89.7 ± 4.6 (3) | (0) | – | |
| 20 min | 89.2 ± 3.8 (5) | (0) | – | |
| 30 min | 91.2 ± 2.3 (5) | (0) | – | |
| 40 min | 91.8 ± 4.7 (5) | (0) | – | |
| 50 min | 92.0 ± 4.7 (5) | (0) | – | |
| 60 min | 93.6 ± 4.3 (5) | (0) | – |
Values given are mean ±standard deviation (number of animals with available data). ″(0)″ indicates that no data are available for that variable and time. Comparisons were made at each timepoint if more than 1 animal had data available from each group. Baseline: Measurements upon initial evaluation of animal, Baseline 2: Measurements after animals were instrumented and stabilized before intervention and toxin administration.