Table 1.

Genes tested by current next generation sequencing panels

Epigenetic regulators	IDH1, IDH2, EZH2, ASXL1, DNMT3A, TET2, SUZ12, KDM6A/UTX
Spliceosomal genes	SF3B1, U2AF1, SRSF2, ZRSR2
Cytoplasmic tyrosine kinases	JAK1, JAK2, JAK3, ABL1
Receptor tyrosine kinases	FLT3, KIT
Signaling molecules	CBL, CBLB, NRAS, KRAS, HRAS
Cytokine receptors	MPL, IL7R, CSF3R
Transcriptional factors	GATA1, GATA2, CEBPA, ETV6, RUNX1, STAT3, PAX5, IKZF1
Tumor suppressors	TP53, WT1
Phosphatase	PTPN11
Other	FBXW7, CREBBP, NOTCH1, BCOR, NPM1