TABLE 2.

Tissue Distribution (%ID/g) of ⁶⁴Cu-TP3982 and ^99mTc-TP3982 in Nude Mice Bearing T47D (n = 5)

	4 h			24 h
Tissue	64Cu-TP3982	99mTc-TP3982	P	64Cu-TP3982	99mTc-TP3982	P
Muscle	1.77 ± 0.33	0.29 ± 0.07	0.01	2.68 ± 0.30	0.17 ± 0.04	0.00
Intestine	8.31 ± 2.83	0.64 ± 0.15	0.01	8.97 ± 3.03	0.28 ± 0.03	0.00
Heart	3.90 ± 1.07	1.25 ± 0.11	0.01	6.41 ± 1.92	0.47 ± 0.03	0.00
Lungs	50.40 ± 8.06	0.90 ± 0.11	0.01	11.02 ± 5.13	0.54 ± 0.05	0.00
Blood	2.27 ± 0.80	0.82 ± 0.08	0.01	2.80 ± 0.97	0.23 ± 0.01	0.00
Spleen	4.12 ± 1.52	1.98 ± 0.38	0.01	4.74 ± 1.61	1.29 ± 0.08	0.00
Kidneys	9.08 ± 3.23	7.70 ± 1.26	0.01	10.56 ± 3.59	5.18 ± 0.45	0.01
Liver	25.69 ± 2.73	10.13 ± 1.69	0.01	21.15 ± 8.08	6.11 ± 0.50	0.00
Tumor	10.81 ± 2.12	0.51 ± 0.05	0.01	17.04 ± 0.73	0.77 ± 0.12	0.00
T/M ratio	6.42 ± 2.30	1.86 ± 0.59	0.01	6.43 ± 0.86	4.83 ± 1.31	0.05
T/B ratio	5.96 ± 4.32	0.63 ± 0.12	0.01	6.99 ± 3.40	3.29 ± 0.55	0.04

T/M ratio = tumor-to-muscle ratio; T/B ratio = tumor-to-blood ratio.