TABLE 3.

Four-Hour and 24-Hour Tissue Distribution (%ID/g) of ⁶⁴Cu-TP3982 Before and After Receptor Blocking in Mice Bearing T47D Tumors (n = 4)

	4 h			24 h
Tissue	Before	After	P	Before	After	P
Muscle	1.77 ± 0.33	1.16 ± 0.19	0.01	2.68 ± 0.30	1.61 ± 0.39	0.00
Intestine	8.31 ± 2.83	5.20 ± 0.59	0.01	8.97 ± 3.03	6.19 ± 0.63	0.02
Heart	3.90 ± 1.07	2.89 ± 0.34	0.01	6.41 ± 1.92	4.37 ± 0.60	0.01
Lungs	50.40 ± 8.06	5.36 ± 0.33	0.01	11.02 ± 5.13	7.12 ± 0.69	0.08
Blood	2.27 ± 0.80	2.00 ± 0.15	0.01	2.80 ± 0.97	2.91 ± 0.29	0.75
Spleen	4.12 ± 1.52	14.93 ± 4.01	0.01	4.74 ± 1.61	4.55 ± 1.15	0.77
Kidneys	9.08 ± 3.23	5.78 ± 0.24	0.01	10.56 ± 3.59	8.38 ± 0.28	0.13
Liver	25.69 ± 2.73	30.26 ± 3.59	0.12	21.15 ± 8.08	20.64 ± 1.84	0.88
Tumor	10.81 ± 2.12	6.42 ± 1.14	0.02	17.04 ± 0.73	12.06 ± 2.87	0.01
T/M ratio	6.42 ± 2.30	5.73 ± 1.79	0.83	6.43 ± 0.86	7.92 ± 3.26	0.34
T/B ratio	5.96 ± 4.32	3.21 ± 0.50	0.19	6.99 ± 3.40	4.17 ± 1.00	0.03

T/M ratio = tumor-to-muscle ratio; T/B ratio = tumor-to-blood ratio.