Figure 5.

(A) Distribution of Biomarker CRT Score as a function of a composite MADITCRT Score.⁵ With higher MADIT-CRT Scores (>5), a subset of patients could still be identified with a high probability of a favorable response to CRT using the Biomarker CRT Score (bracket indicates p<0.05). Thus, despite classifying patients using a previously established CRT clinical scoring algorithm, a subset of patients could be identified over and above this clinical scoring algorithm. (B) Using an adaptive design and recursive partitioning (Supplemental Methods) demonstrated that the Biomarker CRT Score identified a subset of patients with a low likelihood of response to CRT, which would not have been realized by a clinical scoring algorithm alone.