Table 2A.
Biomarker Selection Results Used to Develop Final Biomarker Cassette for Biomarker CRT Score*
| Biomarker | Cutoff | Percent of Significant Bootstrap Univariable Models | Median (2.5th, 97.5th Percentiles) Odds Ratio* from Bootstrap Models | Mean AIC from Bootstrap Response Score Model (Model Included Biomarker and all preceding Biomarkers) | Contribution to Biomarker Response Score |
|---|---|---|---|---|---|
| sTNFr-II (pg/mL) | 7,090 | 91.4% | 1.64 (1.22, 2.19) | 1040.93 | ≥ 7,090 = 1 point |
| sST-2 (pg/mL) | 23,721 | 90.7% | 1.65 (1.23, 2.23) | 1033.45 | ≥ 23,721 = 1 point |
| CRP (ng/mL) | 7,381 | 74.6% | 1.50 (1.10, 2.05) | 1031.02 | ≥ 7,381 = 1 point |
| MMP-2 (pg/mL) | 982,000 | 70.1% | 1.49 (1.09, 2.03) | 1028.69 | ≥ 982,000 = 1 point |
| TIMP-2 (pg/mL) | 124,257 | 63.7% | 1.50 (1.06, 2.12) | 1029.00 | Not selected |
| NT-proBNP (pmol/L) | 1,430 | 36.9% | 1.27 (0.95, 1.69) | 1033.74 | Not selected |
| sGp130 (pg/mL) | 218,820 | 31.9% | 1.25 (0.93, 1.70) | 1032.23 | Not selected |
| TIMP-1 (pg/mL) | 173,634 | 30.1% | 1.27 (0.92, 1.78) | 1031.38 | Not selected |
| IFNg (pg/mL) | 3.4 | 30.0% | 1.29 (0.91, 1.83) | 1030.00 | Not selected |
| sIL-2ra (pg/mL) | 978 | 16.7% | 1.16 (0.87, 1.54) | 1030.74 | Not selected |
| MMP-9 (pg/mL) | 155,246 | 6.4% | 1.05 (0.77, 1.43) | 1032.72 | Not selected |
| TIMP-4 (pg/mL) | 2,923 | 5.5% | 0.95 (0.70, 1.30) | 1033.07 | Not selected |
*
Odds Ratio of CRT Response, comparing < cutoff to ≥ cutoff
*
The 12 candidate biomarkers were subjected to Bootstrapping modeling and a set-point of >70% of the univariate models was established for final inclusion.