Table 2B.

Changes in the Primary Response Variable from the SMART-AV Trial as a Function of Biomarker CRT Score^*

Biomarker CRT Score	Absolute Change in LVESV*	Relative Change in LVESV+
0	−30 ± 39	−22.1% ± 30.5%
1	−25 ± 50	−15.7% ± 34.2%
2	−14 ± 43	−9.1% ± 35.4%
3	−13 ± 41	−6.9% ± 31.8%
4	−5 ± 36	−0.2% ± 25.9%

^*The Biomarker CRT Score when considered as 5 ordinal treatment groups, was associated with a significant difference in both absolute and percent changes in LVESV (absolute change: Cuzick trend test statistic=5.2, *= p<0.001; relative change: Cuzick trend test statistic=5.9, +p<0.001). Specifically, with a lower Biomarker CRT Score the mean decrease in LVESV was greater, whereas with a higher Biomarker CRT Score a much smaller mean decrease in LVESV occurred.