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Reaction Development and Optimizationa
 | ||
|---|---|---|
| Entry | PR3 Reagent | Yield %b |
| 1 | Triphenylphosphine (PPh3, 4) | 4 |
| 2 | Tri-tert-butylphosphine (P(tBu)3, 5) | 24 |
| 3 | Tricyclohexylphosphine (PCy3, 6) | 46 |
| 4 | Tributylphosphine (PBu3, 7) | 66 |
| 5 | Triethylphosphine (PEt3, 8) | 81 |
| 6 | Trimethylphosphine (PMe3, 9) | 39c |
| 7 | Triethylphosphite (P(OEt)3, 10) | 8 |
| 8 | Tris(dimethylamino)phosphine (P(NMe)3, 11) | 10 |
0.5 mmol scale.
Yields determined via GC vs internal standard.
PMe3 was introduced as a 1 M solution in THF.
