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Regulation of FMR4 in a variety of ways. (A) FMR4 binds histone-modifying enzymes to develop complexes which can regulate transcription of the target gene. (B) FMR4 can play role in DNA mismatch repair, transcriptional inhibition, and apoptosis regulation as a negatively regulating factor of MBD4. (C) FMR4 can induce the changes of transcriptional levels by directly aiming at mRNAs splicing, editing, or stability, or by forming scaffolds for the recruitment of functional protein.
