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. 2019 May 22;10:446. doi: 10.3389/fgene.2019.00446

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Copyright © 2019 Huang, Zhu, Wu, Cui and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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It is an illustration of how the BC2/200-FMRP complex recognizes and inhibits the translation of mRNAs. (A) The NT of FMRP can bind to the targeted mRNAs simultaneously via five regions of the longer stem loop of BC1 RNAs and G-quarter, and it would repress steadily the translation of the targeted mRNAs. (B) Poly(A)-binding protein (PABP) can connect with BC1 that actually act on the poly(A) tail of targeted mRNAs. (C) Other interactions also play a role in preventing the targeted mRNAs being.