Table 1.

Features of epilepsy consistent with ferroptosis.

Feature	Description	References
Elevated lipid peroxidation products	F2-Isoprostanes, 4-hydroxy-2-nonenal protein adducts and malonaldehyde were enhanced.	Pecorelli et al., 2015; Zhu et al., 2016
ACSL4 inhibitors reduced epileptic seizures	Treatment with pioglitazone, a recently discovered ACSL4 inhibitor, abrogated the increased risk of epilepsy.	Abdallah, 2010; Simeone et al., 2017
12/15-lipoxygenase inhibitors reduced the risk of epileptic seizures	Baicalein, a 12/15-lipoxygenase inhibitor, was found to abnegate the increased risk of epilepsy in rodents.	Mao et al., 2014
Increased 5-lipoxygenase activity	5-Lipoxygenase activity was augmented in KA-induced epilepsy.	Manev et al., 1998
GPX4	Selenocysteine-containing GPX4 prevented epileptic seizures.	Ingold et al., 2018
Iron overload	Accumulation of iron was found in epileptic patients; injection of iron in brain could trigger epileptic discharges.	Willmore et al., 1978a,b
Possible clinical benefits of iron chelation	Treatment with deferoxamine, a common iron chelator, could suppress epilepsy.	Zou et al., 2017

The listed features of epileptic seizures were in line with a role for ferroptosis in the disease etiology.