Figure 1.

Establishment of single nodule orthotopic NSCLC models. (A) Representative 2D delineated CT images of selected time points after H1299 cell suspension injection in the right lung. Tumors, right and left lung are delineated in red, green and blue, respectively. (B) Macroscopic and histological confirmation of presence of a single tumor nodule in the right lung indicated with an arrow. (C) Tumor quantification over time of a representative orthotopic H1299-wildtype lung tumor. (D) Tumor quantification over time of three orthotopic H1299-luciferase lung tumors: A7, C7, and D8 (presenting a central calcification). (E) Normalized H1299-luciferase (from D) tumor volumes to total right lung volume quantification. NSCLC, non-small cell lung cancer.