Table 1.
Dose-volume histogram metrics for different structures (ITV, PTV, right/left lung, heart, spinal cord) for a representative mouse case bearing a H1299-wt tumor (4 mm3) using four different radiation plans (see methodology), two collimators (3 mm and 5 mm), and a prescribed dose of 2 Gy
| Structure | Collimator | 3 mm | 5 mm | ||||||
| Plan | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
| ITV | Dmean (Gy) | 2.00 | 1.99 | 2.00 | 1.98 | 2.02 | 1.99 | 2.01 | 2.00 |
| Dmin (Gy) | 1.57 | 1.72 | 1.78 | 1.77 | 1.94 | 1.91 | 1.92 | 1.91 | |
| Dmax (Gy) | 2.16 | 2.18 | 2.16 | 2.16 | 2.16 | 2.14 | 2.14 | 2.17 | |
| V95 (%) | 98.03 | 99.69 | 99.11 | 95.67 | 100.00 | 100.00 | 100.00 | 100.00 | |
| D95 (Gy) | 1.93 | 1.94 | 1.94 | 1.90 | 1.98 | 1.95 | 1.97 | 1.95 | |
| D5 (Gy) | 2.07 | 2.07 | 2.07 | 2.06 | 2.10 | 2.07 | 2.09 | 2.08 | |
| D1 (Gy) | 2.12 | 2.11 | 2.11 | 2.12 | 2.13 | 2.10 | 2.12 | 2.13 | |
| PTV | Dmean (Gy) | 1.96 | 1.99 | 1.98 | 1.97 | 2.06 | 2.03 | 2.05 | 2.04 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 2.20 | 2.18 | 2.17 | 2.20 | 2.20 | 2.17 | 2.18 | 2.20 | |
| V95 (%) | 86.61 | 92.80 | 86.68 | 82.29 | 99.88 | 99.94 | 99.95 | 99.83 | |
| D95 (Gy) | 1.46 | 1.80 | 1.68 | 1.67 | 1.98 | 1.96 | 1.97 | 1.94 | |
| D5 (Gy) | 2.11 | 2.11 | 2.10 | 2.12 | 2.14 | 2.10 | 2.12 | 2.14 | |
| D1 (Gy) | 2.14 | 2.13 | 2.13 | 2.15 | 2.16 | 2.12 | 2.14 | 2.16 | |
| Right lung | Dmean (Gy) | 0.73 | 0.35 | 0.54 | 0.51 | 1.22 | 0.61 | 0.91 | 0.87 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 2.21 | 2.20 | 2.17 | 2.22 | 2.22 | 2.17 | 2.18 | 2.24 | |
| V95 (%) | 24.55 | 11.20 | 4.54 | 4.20 | 47.73 | 21.74 | 15.15 | 14.50 | |
| D95 (Gy) | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 | 0.02 | |
| D5 (Gy) | 2.10 | 2.04 | 1.84 | 1.82 | 2.13 | 2.08 | 2.08 | 2.09 | |
| D1 (Gy) | 2.13 | 2.10 | 2.07 | 2.08 | 2.16 | 2.11 | 2.11 | 2.15 | |
| Left lung | Dmean (Gy) | 0.01 | 0.57 | 0.29 | 0.24 | 0.01 | 0.98 | 0.48 | 0.39 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 0.02 | 2.24 | 1.14 | 0.95 | 0.03 | 2.22 | 1.14 | 0.97 | |
| V95 (%) | 0.00 | 19.26 | 0.00 | 0.00 | 0.00 | 36.68 | 0.00 | 0.00 | |
| D95 (Gy) | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | |
| D5 (Gy) | 0.01 | 2.11 | 1.06 | 0.77 | 0.02 | 2.13 | 1.08 | 0.86 | |
| D1 (Gy) | 0.01 | 2.16 | 1.09 | 0.86 | 0.02 | 2.15 | 1.10 | 0.91 | |
| Heart | Dmean (Gy) | 0.01 | 0.01 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.07 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 0.11 | 0.13 | 0.09 | 0.69 | 1.82 | 1.79 | 0.93 | 0.94 | |
| V95 (%) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| D95 (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | |
| D5 (Gy) | 0.02 | 0.02 | 0.02 | 0.11 | 0.04 | 0.04 | 0.04 | 0.42 | |
| D1 (Gy) | 0.02 | 0.02 | 0.02 | 0.41 | 0.31 | 0.11 | 0.27 | 0.72 | |
| Spinal cord | Dmean (Gy) | 0.01 | 0.01 | 0.01 | 0.01 | 0.04 | 0.11 | 0.06 | 0.06 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 0.07 | 0.51 | 0.24 | 0.31 | 0.88 | 1.94 | 1.01 | 0.85 | |
| V95 (%) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | |
| D95 (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | |
| D5 (Gy) | 0.02 | 0.03 | 0.02 | 0.02 | 0.08 | 0.69 | 0.30 | 0.33 | |
| D1 (Gy) | 0.03 | 0.06 | 0.04 | 0.07 | 0.38 | 1.61 | 0.83 | 0.67 | |
Dmax, maximum PTV dose (Gy); Dmean, mean PTV dose (Gy); Dmin, minimum PTV dose (Gy); ITV, internal target volume; PTV, planned target volume; V95, Percentage (%) of PTV receiving 95% of the prescribed dose.
Dmean: Mean PTV dose (Gy),Dmin: Minimum PTV dose (Gy), Dmax: Maximum PTV dose (Gy), V95: Percentage (%) of PTV receiving 95% of the prescribed dose, and D95, D5, D1 are the doses to the hottest 95%, 5%, or1% delineated structure.