Table 2.
Dose–volume histogram metrics for different structures (ITV, PTV, right/left lung, heart, spinal cord) for a representative mouse case bearing a H1299-wt tumor (10.4 mm3) using four different radiation plans (see methodology), two collimators (3 mm and 5 mm), and a prescribed dose of 2 Gy
| Structure | Collimator | 3 mm | 5 mm | ||||||
| Plan | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
| ITV | Dmean (Gy) | 1.94 | 1.95 | 1.95 | 1.94 | 1.98 | 1.99 | 1.99 | 2.00 |
| Dmin (Gy) | 0.58 | 0.73 | 0.90 | 1.20 | 1.88 | 1.89 | 1.90 | 1.90 | |
| Dmax (Gy) | 2.14 | 2.15 | 2.15 | 2.16 | 2.15 | 2.15 | 2.14 | 2.18 | |
| V95 (%) | 85.34 | 87.28 | 87.6 | 79.13 | 99.87 | 99.98 | 99.99 | 99.91 | |
| D95 (Gy) | 1.68 | 1.78 | 1.76 | 1.77 | 1.94 | 1.94 | 1.95 | 1.94 | |
| D5 (Gy) | 2.04 | 2.03 | 2.04 | 2.03 | 2.06 | 2.06 | 2.06 | 2.08 | |
| D1 (Gy) | 2.08 | 2.08 | 2.09 | 2.09 | 2.09 | 2.09 | 2.09 | 2.13 | |
| PTV | Dmean (Gy) | 1.79 | 1.86 | 1.84 | 1.83 | 2.01 | 2.02 | 2.02 | 2.03 |
| Dmin (Gy) | 0.04 | 0.07 | 0.17 | 0.48 | 1.69 | 1.88 | 1.84 | 1.77 | |
| Dmax (Gy) | 2.19 | 2.16 | 2.15 | 2.16 | 2.16 | 2.17 | 2.16 | 2.20 | |
| V95 (%) | 69.83 | 76.85 | 65.81 | 58.17 | 98.66 | 99.98 | 99.88 | 99.45 | |
| D95 (Gy) | 0.71 | 1.02 | 1.23 | 1.27 | 1.93 | 1.95 | 1.95 | 1.94 | |
| D5 (Gy) | 2.08 | 2.07 | 2.07 | 2.07 | 2.09 | 2.10 | 2.09 | 2.14 | |
| D1 (Gy) | 2.12 | 2.10 | 2.10 | 2.11 | 2.11 | 2.12 | 2.11 | 2.16 | |
| Right lung | Dmean (Gy) | 0.54 | 0.32 | 0.43 | 0.37 | 0.98 | 0.61 | 0.80 | 0.69 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 2.21 | 2.20 | 2.15 | 2.16 | 2.18 | 2.17 | 2.18 | 2.22 | |
| V95 (%) | 17.68 | 9.89 | 2.25 | 1.80 | 34.98 | 21.00 | 10.96 | 10.14 | |
| D95 (Gy) | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | |
| D5 (Gy) | 2.07 | 2.02 | 1.44 | 1.36 | 2.08 | 2.08 | 2.04 | 2.05 | |
| D1 (Gy) | 2.11 | 2.08 | 2.02 | 1.99 | 2.11 | 2.10 | 2.09 | 2.13 | |
| Left lung | Dmean (Gy) | 0.01 | 0.47 | 0.26 | 0.20 | 0.01 | 0.97 | 0.49 | 0.37 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 0.02 | 2.21 | 1.14 | 0.97 | 0.04 | 2.20 | 1.12 | 1.00 | |
| V95 (%) | 0.00 | 15.03 | 0.00 | 0.00 | 0.00 | 35.06 | 0.00 | 0.00 | |
| D95 (Gy) | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | |
| D5 (Gy) | 0.01 | 2.07 | 1.05 | 0.79 | 0.02 | 2.12 | 1.07 | 0.90 | |
| D1 (Gy) | 0.01 | 2.13 | 1.08 | 0.89 | 0.03 | 2.14 | 1.08 | 0.94 | |
| Heart | Dmean (Gy) | 0.01 | 0.01 | 0.01 | 0.07 | 0.04 | 0.02 | 0.03 | 0.13 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 1.49 | 0.03 | 0.75 | 1.27 | 2.07 | 1.08 | 1.05 | 1.78 | |
| V95 (%) | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.00 | 0.00 | |
| D95 (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | |
| D5 (Gy) | 0.02 | 0.01 | 0.02 | 0.54 | 0.05 | 0.04 | 0.05 | 0.82 | |
| D1 (Gy) | 0.03 | 0.02 | 0.02 | 0.84 | 1.17 | 0.06 | 0.59 | 0.90 | |
| Spinal cord | Dmean (Gy) | 0.01 | 0.01 | 0.01 | 0.01 | 0.06 | 0.03 | 0.05 | 0.04 |
| Dmin (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| Dmax (Gy) | 0.19 | 0.19 | 0.11 | 0.23 | 4.46 | 2.88 | 2.33 | 2.06 | |
| V95 (%) | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.01 | 0.00 | |
| D95 (Gy) | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | |
| D5 (Gy) | 0.02 | 0.02 | 0.02 | 0.02 | 0.24 | 0.09 | 0.21 | 0.21 | |
| D1 (Gy) | 0.03 | 0.03 | 0.02 | 0.04 | 0.92 | 0.40 | 0.50 | 0.47 | |
Dmax, maximum PTV dose (Gy); Dmin, minimum PTV dose (Gy); V95, percentage (%) of PTVreceiving 95% of the prescribed dose, and D95, D5, D1 are the doses to the hottest 95%, 5%, or 1% delineated structure.
Dmean: Mean PTV dose (Gy),Dmin: Minimum PTV dose (Gy), Dmax: Maximum PTV dose (Gy), V95: Percentage (%) of PTV receiving 95% of the prescribed dose, and D95, D5, D1 are the doses to the hottest 95%, 5%, or 1% delineated structure.