Figure 3. Effects of FLT4 rs307826 (A>G, T494A) on sorafenib cytotoxicity.
A) HUVECs were transfected with either the A or the G allele, and then treated with sorafenib with and without VEGF-C stimulation. B) Results were replicated in HEK-293 cells. All experiments were conducted in triplicate (n=9 at for each concentration). Relative fluorescence units (RFUs) were generated to determine the percentage of viable cells present. The mean±SEM of RFUs is shown.