Table 1.
Relative shift in geometric mean (95% CI) breast volume between tertiles of each phenol and phthalate biomarker across B1 and B4a
| EDC | Overall Testb (p-value) |
Middle vs Lowest Tertile (ref) |
Highest vs Lowest Tertile (ref) |
Highest vs Middle Tertile (ref) |
Trendc (p-value) |
|---|---|---|---|---|---|
| 2,4-dichlorophenol | 0.108 | 0.97 (0.89, 1.05) | 0.91* (0.84, 0.99) | 0.94 (0.86, 1.03) | 0.032* |
| 2,5-dichlorophenol | 0.198 | 1.02 (0.93, 1.11) | 1.07 (0.99, 1.16) | 1.05 (0.97, 1.13) | 0.057 |
| Benzophenone-3 | 0.695 | 1.03 (0.95, 1.11) | 1.03 (0.96, 1.12) | 1.01 (0.94, 1.09) | 0.380 |
| BPA | 0.356 | 0.95 (0.88, 1.02) | 0.96 (0.88, 1.05) | 1.02 (0.94, 1.11) | 0.448 |
| Methyl paraben | 0.679 | 0.97 (0.89, 1.05) | 0.99 (0.91, 1.08) | 1.03 (0.95, 1.11) | 0.804 |
| MBP | 0.329 | 0.95 (0.88, 1.02) | 0.97 (0.90, 1.04) | 1.02 (0.95, 1.10) | 0.453 |
| MBzP | 0.184 | 0.93 (0.87, 1.01) | 0.95 (0.87, 1.04) | 1.02 (0.94, 1.10) | 0.243 |
| MCNP | 0.043* | 0.94 (0.86, 1.02) | 1.03 (0.96, 1.10) | 1.10* (1.02, 1.18) | 0.369 |
| MCOP | 0.852 | 1.03 (0.94, 1.12) | 1.02 (0.94, 1.10) | 0.99 (0.91, 1.08) | 0.706 |
| MCPP | 0.708 | 0.97 (0.90, 1.06) | 1.01 (0.94, 1.09) | 1.04 (0.95, 1.13) | 0.766 |
| MECPP | 0.735 | 0.97 (0.89, 1.05) | 1.00 (0.92, 1.08) | 1.03 (0.94, 1.13) | 0.936 |
| MEHHP | 0.919 | 0.99 (0.91, 1.08) | 1.01 (0.93, 1.09) | 1.02 (0.93, 1.11) | 0.741 |
| MEHP | 0.077 | 0.92* (0.85, 1.00) | 0.93 (0.86, 1.01) | 1.01 (0.93, 1.11) | 0.108 |
| MEOHP | 0.908 | 0.98 (0.91, 1.07) | 0.99 (0.92, 1.07) | 1.01 (0.93, 1.09) | 0.855 |
| MEP | 0.600 | 1.02 (0.94, 1.12) | 1.04 (0.96, 1.14) | 1.02 (0.94, 1.11) | 0.296 |
| MHBP | 0.767 | 0.97 (0.90, 1.05) | 1.00 (0.92, 1.07) | 1.02 (0.95, 1.10) | 0.902 |
| MHiBP | 0.915 | 0.99 (0.91, 1.06) | 1.00 (0.91, 1.09) | 1.01 (0.94, 1.09) | 0.949 |
| MiBP | 0.517 | 1.04 (0.96, 1.12) | 1.00 (0.91, 1.09) | 0.96 (0.89, 1.04) | 0.967 |
| MMP | 0.544 | 0.97 (0.90, 1.05) | 1.02 (0.94, 1.10) | 1.05 (0.96, 1.13) | 0.716 |
| Propyl paraben | 0.811 | 1.02 (0.94, 1.11) | 1.02 (0.94, 1.11) | 1.00 (0.92, 1.08) | 0.582 |
| Triclosan | 0.226 | 0.96 (0.89, 1.04) | 0.93 (0.85, 1.01) | 0.96 (0.89, 1.04) | 0.070 |
a
Estimating average association across B1 and B4 EDC measurements using a multivariable GEE model adjusting for age at B1 EDC measurement, age at B4 EDC measurement, BMI z-score at B1, BMI z-score at B4, and maternal education
b
Overall test whether EDC category improves model fit (multivariate Wald test)
c
Trend evaluated by modeling the log(median) concentration within tertiles as a continuous variable
*
p<0.05,
**p<0.01,
***p<0.001