Table 2.
Relative shift in geometric mean (95% CI) fibroglandular volume between tertiles of each phenol and phthalate biomarker across B1 and B4a
| EDC | Overall Testb (p-value) |
Middle vs Lowest Tertile (ref) |
Highest vs Lowest Tertile (ref) |
Highest vs Middle Tertile (ref) |
Trendc (p-value) |
|---|---|---|---|---|---|
| 2,4-dichlorophenol | 0.269 | 0.93 (0.84, 1.03) | 0.92 (0.82, 1.03) | 0.98 (0.88, 1.10) | 0.152 |
| 2,5-dichlorophenol | 0.578 | 1.05 (0.95, 1.17) | 1.05 (0.94, 1.17) | 1.00 (0.91, 1.10) | 0.382 |
| Benzophenone-3 | 0.811 | 1.00 (0.91, 1.11) | 1.03 (0.93, 1.14) | 1.03 (0.93, 1.13) | 0.433 |
| BPA | 0.008** | 0.88** (0.80, 0.97) | 1.01 (0.90, 1.12) | 1.14* (1.03, 1.26) | 0.879 |
| Methyl paraben | 0.824 | 0.99 (0.88, 1.10) | 1.01 (0.92, 1.12) | 1.03 (0.94, 1.13) | 0.876 |
| MBP | 0.169 | 0.92 (0.84, 1.00) | 0.96 (0.87, 1.06) | 1.05 (0.96, 1.15) | 0.497 |
| MBzP | 0.582 | 0.95 (0.86, 1.05) | 0.99 (0.88, 1.10) | 1.04 (0.94, 1.14) | 0.763 |
| MCNP | 0.080 | 0.97 (0.88, 1.08) | 1.07 (0.97, 1.18) | 1.10* (1.01, 1.20) | 0.120 |
| MCOP | 0.189 | 1.04 (0.93, 1.16) | 1.09 (0.99, 1.21) | 1.05 (0.95, 1.16) | 0.073 |
| MCPP | 0.854 | 1.02 (0.92, 1.13) | 1.03 (0.93, 1.13) | 1.00 (0.90, 1.12) | 0.616 |
| MECPP | 0.719 | 1.01 (0.91, 1.12) | 1.05 (0.94, 1.16) | 1.04 (0.92, 1.16) | 0.374 |
| MEHHP | 0.708 | 0.99 (0.89, 1.11) | 1.04 (0.93, 1.15) | 1.04 (0.94, 1.16) | 0.489 |
| MEHP | 0.237 | 0.91 (0.82, 1.01) | 0.98 (0.88, 1.08) | 1.07 (0.95, 1.20) | 0.715 |
| MEOHP | 0.554 | 0.98 (0.88, 1.08) | 1.03 (0.93, 1.15) | 1.06 (0.96, 1.17) | 0.549 |
| MEP | 0.194 | 1.03 (0.93, 1.14) | 1.09 (0.99, 1.21) | 1.06 (0.96, 1.17) | 0.065 |
| MHBP | 0.687 | 0.97 (0.88, 1.08) | 1.01 (0.92, 1.11) | 1.04 (0.95, 1.14) | 0.772 |
| MHiBP | 0.588 | 0.99 (0.89, 1.10) | 1.04 (0.93, 1.16) | 1.05 (0.96, 1.15) | 0.516 |
| MiBP | 0.802 | 1.03 (0.93, 1.14) | 1.03 (0.93, 1.15) | 1.00 (0.91, 1.10) | 0.489 |
| MMP | 0.252 | 1.02 (0.93, 1.12) | 1.08 (0.98, 1.20) | 1.06 (0.96, 1.17) | 0.116 |
| Propyl paraben | 0.812 | 1.01 (0.91, 1.12) | 1.03 (0.94, 1.14) | 1.02 (0.93, 1.12) | 0.468 |
| Triclosan | 0.130 | 0.91* (0.83, 1.00) | 0.93 (0.83, 1.04) | 1.02 (0.92, 1.13) | 0.218 |
a
Estimating average association across B1 and B4 EDC measurements using a multivariable GEE model adjusting for age at B1 EDC measurement, age at B4 EDC measurement, BMI z-score at B1, BMI z-score at B4, and maternal education
b
Overall test whether EDC category improves model fit (multivariate Wald test)
c
Trend evaluated by modeling the log(median) concentration within tertiles as a continuous variable
*
p<0.05,
**
p<0.01,
***p<0.001