Fig 4. Stratum-specific effects of cinacalcet initiation on hospitalization (two-level stratification).
HRs were adjusted for age, gender, cause of CKD, smoking status, duration of hemodialysis, history of hyperparathyroidism treatment, baseline comorbidities (diabetes and cardiovascular disease), baseline creatinine, baseline total protein, time-varying medications (VDRA, phosphate binders, iron supplements) and time-varying laboratory tests (Kt/V, iPTH, Ca, P, albumin, ferritin, iron, and hemoglobin). The P-values for the interaction (Wald test with one degree of freedom) were 0.077 for all-cause hospitalizations, 0.642 for cardiovascular-related hospitalizations, 0.530 for infection-related hospitalizations, and 0.024 for VA-related hospitalizations. Abbreviations: iPTH, intact parathyroid hormone.