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. 2019 May 29;14(5):e0216961. doi: 10.1371/journal.pone.0216961

Table 2. GRADE evidence profile: Surgery plus physiotherapy vs physiotherapy alone.

Quality Assessment Summary of Findings
Outcome
(No. of studies; design)
Limitations Inconsistency Indirectness Imprecision Publication Bias Surgery plus Physiotherapy Physiotherapy alone SMD / WMD
(95% CI)
Quality
Pain at 3 months
(3 RCTs) [10,26,28]
Serious limitations No serious inconsistency No serious indirectness No serious imprecisions Unlikely 138/300 162/300 WMD -0.39
(-1.02–0.23)
⊕⊕⊕⊝
Moderate
Pain at 6 months
(3 RCTs) [10,26,28]
Serious limitations No serious inconsistency No serious indirectness No serious imprecisions Unlikely 144/310 166/310 WMD -0.36
(-1.02–0.29)
⊕⊕⊕⊝
Moderate
Pain at 1 year
(3 RCTs) [10,26,28]
Serious limitations No serious inconsistency No serious indirectness No serious imprecisions Unlikely 147/317 170/317 WMD -0.67
(-1.23 –-0.11)
⊕⊕⊕⊝
Moderate
Pain at 2 years
(2 RCTs) [10, 28]
Serious limitations No serious inconsistency No serious indirectness No serious imprecisions Unlikely 127/261 134/261 WMD -0.67
(-1.23 –-0.12)
⊕⊕⊕⊝
Moderate
Pain at 5 years
(1 RCT) [29]
Serious limitations N/A No serious indirectness Serious imprecisions Unlikely 57/109 52/109 WMD -0.30
(-1.54–0.94)
⊕⊕⊝⊝
Low
Pain at 10 years
(1 RCT) [31]
Serious limitations N/A No serious indirectness Serious imprecisions Unlikely 44/90 46/90 WMD 1.00
(-0.24–2.24)
⊕⊕⊝⊝
Low
Function at 3 months
(2 RCTs) [26,28]
Serious limitations Serious inconsistency No serious indirectness Serious imprecisions Unlikely 84/184 100/184 SMD 0.11
(-0.57–0.79)
⊕⊝⊝⊝
Very low
Function at 6 months
(3 RCTs) [26,28]
Serious limitations No serious inconsistency No serious indirectness No serious imprecisions Unlikely 144/310 166/310 SMD 0.15
(-0.14–0.43)
⊕⊕⊕⊝
Moderate
Function at 1 year
(2 RCTs) [26,28]
Serious limitations Serious inconsistency No serious indirectness Serious imprecisions Unlikely 92/197 105/197 SMD 0.11
(-0.46–0.69)
⊕⊝⊝⊝
Very low
Function at 2–2.5 years
(3 RCTs) [28,30]
Serious limitations No serious inconsistency No serious indirectness Serious imprecisions Unlikely 146/301 155/301 SMD 0.31
(0.08–0.54)
⊕⊕⊝⊝
Low
Function at 5 years
(1 RCT) [29]
Serious limitations N/A No serious indirectness Serious imprecisions Unlikely 57/109 52/109 SMD 0.14
(-0.24–0.51)
⊕⊕⊝⊝
Low
Function at ≥10 years
(2 RCTs) [11,31]
Serious limitations No serious inconsistency No serious indirectness Serious imprecisions Unlikely 62/136 74/136 SMD 0.22
(-0.12–0.56)
⊕⊕⊝⊝
Low