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. 2019 May 3;68(17):388–395. doi: 10.15585/mmwr.mm6817a3

TABLE. Number and age-adjusted rate of drug overdose deaths* involving cocaine and psychostimulants with abuse potential,§, by opioid involvement,** sex, age group, race and Hispanic origin,†† U.S. Census region, urbanization level,§§ and selected states¶¶ — United States, 2016 and 2017.

Decedent characteristic Involving cocaine
Involving psychostimulants with abuse potential
2016
2017
Change from 2016 to 2017***
2016
2017
Change from 2016 to 2017***
No. (Rate) No. (Rate) Absolute rate change % Change in rate No. (Rate) No. (Rate) Absolute rate change % Change in rate
Overall
10,375 (3.2)
13,942 (4.3)
1.1†††
34.4†††
7,542 (2.4)
10,333 (3.2)
0.8†††
33.3†††
With any opioid**
7,263 (2.3)
10,131 (3.2)
0.9†††
39.1†††
3,416 (1.1)
5,203 (1.7)
0.6†††
54.5†††
Sex
Male
7,493 (4.7)
10,021 (6.2)
1.5†††
31.9†††
5,348 (3.4)
7,240 (4.5)
1.1†††
32.4†††
Female
2,882 (1.8)
3,921 (2.5)
0.7†††
38.9†††
2,194 (1.4)
3,093 (1.9)
0.5†††
35.7†††
Age group (yrs)

0–14
§§§
§§§
§§§
§§§
11§§§
§§§
§§§
§§§
15–24
757 (1.7)
924 (2.1)
0.4†††
23.5†††
571 (1.3)
780 (1.8)
0.5†††
38.5†††
25–34
2,525 (5.7)
3,463 (7.6)
1.9†††
33.3†††
1,762 (3.9)
2,593 (5.7)
1.8†††
46.2†††
35–44
2,431 (6.0)
3,282 (8.0)
2.0†††
33.3†††
1,831 (4.5)
2,548 (6.2)
1.7†††
37.8†††
45–54
2,629 (6.1)
3,497 (8.3)
2.2†††
36.1†††
1,914 (4.5)
2,477 (5.8)
1.3†††
28.9†††
55–64
1,721 (4.2)
2,335 (5.6)
1.4†††
33.3†††
1,244 (3.0)
1,648 (3.9)
0.9†††
30.0†††
≥65
303 (0.6)
432 (0.8)
0.2†††
33.3†††
206 (0.4)
278 (0.5)
0.1†††
25.0†††
Sex/Age group (yrs)
Male
15–24
553 (2.5)
633 (2.9)
0.4†††
16.0†††
388 (1.7)
499 (2.3)
0.6†††
35.3†††
25–44
3,569 (8.3)
4,784 (11.0)
2.7†††
32.5†††
2,536 (5.9)
3,551 (8.2)
2.3†††
39.0†††
45–64
3,108 (7.6)
4,229 (10.3)
2.7†††
35.5†††
2,251 (5.5)
2,955 (7.2)
1.7†††
30.9†††
Female
15–24
204 (1.0)
291 (1.4)
0.4†††
40.0†††
183 (0.9)
281 (1.3)
0.4†††
44.4†††
25–44
1,387 (3.3)
1,961 (4.6)
1.3†††
39.4†††
1,057 (2.5)
1,590 (3.7)
1.2†††
48.0†††
45–64
1,242 (2.9)
1,603 (3.7)
0.8†††
27.6†††
907 (2.1)
1,170 (2.7)
0.6†††
28.6†††
Race and Hispanic origin††
White, non-Hispanic
6,443 (3.4)
8,614 (4.6)
1.2†††
35.3†††
5,777 (3.0)
7,995 (4.2)
1.2†††
40.0†††
Black, non-Hispanic
2,599 (6.1)
3,554 (8.3)
2.2†††
36.1†††
477 (1.2)
663 (1.6)
0.4†††
33.3†††
Hispanic
1,097 (2.0)
1,438 (2.5)
0.5†††
25.0†††
846 (1.5)
1,125 (2.0)
0.5†††
33.3†††
American Indian/Alaska Native, non-Hispanic
56 (2.1)
65 (2.4)
0.3
14.3
181 (6.9)
222 (8.5)
1.6†††
23.2†††
Asian/Pacific Islander, non-Hispanic
85 (0.4)
129 (0.6)
0.2
50.0
171 (0.8)
218 (1.0)
0.2†††
25.0†††
U.S. Census region of residence
Northeast
2,957 (5.3)
3,860 (7.0)
1.7†††
32.1†††
431 (0.8)
648 (1.2)
0.4†††
50.0†††
Midwest
2,575 (3.9)
3,711 (5.6)
1.7†††
43.6†††
1,176 (1.9)
1,959 (3.1)
1.2†††
63.2†††`
South
4,005 (3.3)
5,365 (4.4)
1.1†††
33.3†††
2,483 (2.1)
3,508 (3.0)
0.9†††
42.9†††
West
838 (1.1)
1,006 (1.3)
0.2†††
18.2†††
3,452 (4.4)
4,218 (5.3)
0.9†††
20.5†††
County urbanization level §§

Large central metro
4,301 (4.2)
5,513 (5.3)
1.1†††
26.2†††
2,561 (2.5)
3,178 (3.0)
0.5†††
20.0†††
Large fringe metro
2,734 (3.5)
3,701 (4.7)
1.2†††
34.3†††
1,235 (1.6)
1,843 (2.3)
0.7†††
43.8†††
Medium metro
2,082 (3.2)
2,945 (4.5)
1.3†††
40.6†††
1,821 (2.8)
2,672 (4.1)
1.3†††
46.4†††
Small metro
569 (2.1)
777 (2.9)
0.8†††
38.1†††
698 (2.6)
972 (3.6)
1.0†††
38.5†††
Micropolitan (non-metro)
474 (1.9)
740 (3.0)
1.1†††
57.9†††
745 (3.0)
994 (4.0)
1.0†††
33.3†††
Non-core (non-metro)
215 (1.3)
266 (1.6)
0.3†††
23.1†††
482 (2.9)
674 (4.1)
1.2†††
41.4†††
States with very good to excellent reporting¶¶ (n = 27)
Alaska
15§§§
17§§§
§§§
§§§
49 (6.3)
66 (9.1)
2.8
44.4
Connecticut
237 (6.9)
284 (8.4)
1.5†††
21.7†††
25 (0.7)
39 (1.2)
0.5
71.4
District of Columbia
89 (13.5)
122 (17.6)
4.1
30.4
§§§
§§§
§§§
§§§
Georgia
209 (2.0)
258 (2.4)
0.4
20.0
243 (2.4)
364 (3.6)
1.2†††
50.0†††
Hawaii
§§§
10§§§
§§§
§§§
102 (6.8)
106 (7.4)
0.6
8.8
Illinois
507 (4.0)
743 (5.7)
1.7†††
42.5†††
112 (0.9)
171 (1.4)
0.5†††
55.6†††
Iowa
15§§§
19§§§
§§§
§§§
80 (2.7)
93 (3.3)
0.6
22.2
Maine
61 (5.0)
94 (7.7)
2.7
54.0
28 (2.3)
44 (3.8)
1.5
65.2
Maryland
314 (5.0)
532 (8.6)
3.6†††
72.0†††
43 (0.8)
65 (1.2)
0.4
50.0
Massachusetts
567 (8.5)
687 (10.1)
1.6†††
18.8†††
45 (0.7)
64 (1.0)
0.3
42.9
Nevada
37 (1.2)
50 (1.6)
0.4
33.3
228 (7.5)
257 (8.3)
0.8
10.7
New Hampshire
61 (5.0)
51 (3.9)
−1.1
−22.0
13§§§
26 (2.3)
§§§
§§§
New Mexico
58 (3.0)
57 (2.9)
−0.1
−3.3
135 (7.1)
158 (8.2)
1.1
15.5
New York
991 (4.9)
1,306 (6.5)
1.6†††
32.7†††
150 (0.8)
191 (1.0)
0.2†††
25.0†††
North Carolina
500 (5.1)
708 (7.2)
2.1†††
41.2†††
115 (1.2)
176 (1.8)
0.6†††
50.0†††
Ohio
1,124 (10.1)
1,556 (14.0)
3.9†††
38.6†††
243 (2.3)
556 (5.3)
3.0†††
130.4†††
Oklahoma
31 (0.8)
45 (1.1)
0.3
37.5
263 (7.1)
275 (7.2)
0.1
1.4
Oregon
26 (0.7)
39 (0.9)
0.2
28.6
150 (3.6)
170 (4.0)
0.4
11.1
Rhode Island
112 (10.7)
111 (11.2)
0.5
4.7
10§§§
12§§§
§§§
§§§
South Carolina
143 (3.0)
234 (4.7)
1.7†††
56.7†††
125 (2.7)
189 (4.0)
1.3†††
48.1†††
Tennessee
249 (3.8)
306 (4.6)
0.8†††
21.1†††
186 (2.9)
320 (5.0)
2.1†††
72.4†††
Utah
48 (1.7)
47 (1.5)
−0.2
−11.8
143 (5.1)
198 (6.8)
1.7†††
33.3†††
Vermont
21 (4.0)
38 (6.9)
2.9
72.5
§§§
§§§
§§§
§§§
Virginia
254 (3.0)
351 (4.1)
1.1†††
36.7†††
76 (0.9)
113 (1.4)
0.5
55.6
Washington
90 (1.2)
111 (1.4)
0.2
16.7
326 (4.4)
392 (5.2)
0.8†††
18.2†††
West Virginia
143 (8.5)
191 (11.6)
3.1†††
36.5†††
117 (7.0)
221 (13.6)
6.6†††
94.3†††
Wisconsin
147 (2.6)
265 (4.8)
2.2†††
84.6†††
76 (1.4)
128 (2.3)
0.9†††
64.3†††
States with good reporting¶¶ (n = 8)
Arizona
82 (1.2)
136 (2.0)
0.8†††
66.7†††
454 (6.7)
572 (8.5)
1.8†††
26.9†††
California
366 (0.9)
433 (1.0)
0.1
11.1
1,579 (3.8)
1,916 (4.6)
0.8†††
21.1†††
Colorado
106 (1.9)
96 (1.7)
−0.2
−10.5
200 (3.6)
301 (5.2)
1.6†††
44.4†††
Kentucky
145 (3.5)
185 (4.3)
0.8
22.9
192 (4.7)
330 (8.0)
3.3†††
70.2†††
Michigan
500 (5.3)
643 (6.7)
1.4†††
26.4†††
88 (0.9)
145 (1.6)
0.7†††
77.8†††
Minnesota
43 (0.8)
68 (1.3)
0.5
62.5
140 (2.6)
161 (2.9)
0.3
11.5
Missouri
103 (1.8)
132 (2.2)
0.4
22.2
185 (3.3)
248 (4.3)
1.0†††
30.3†††
Texas 584 (2.1) 694 (2.4) 0.3††† 14.3††† 577 (2.1) 653 (2.3) 0.2 9.5

Source: National Vital Statistics System, Mortality File. https://wonder.cdc.gov/.

* Deaths are classified using the International Classification of Diseases, Tenth Revision (ICD–10). Drug overdose deaths are identified using underlying cause-of-death codes X40–X44, X60–X64, X85, and Y10–Y14. Rates are age-adjusted using the direct method and the 2000 U.S. standard population, except for age-specific crude rates. All rates are per 100,000 population.

Drug overdose deaths, as defined, that have cocaine (T40.5) as a contributing cause.

§ Drug overdose deaths, as defined, that have psychostimulants with abuse potential (T43.6) as a contributing cause.

Categories of deaths are not exclusive because deaths might involve more than one drug. Summing of categories will result in more than the total number of deaths in a year.

** Drug overdose deaths, as defined, that have any opioid (T40.0–T40.4, and T40.6).

†† Data for Hispanic origin should be interpreted with caution; studies comparing Hispanic origin on death certificates and on census surveys have shown inconsistent reporting on Hispanic ethnicity. Potential race misclassification might lead to underestimates for certain categories, primarily American Indian/Alaska Native non-Hispanic and Asian/Pacific Islander non-Hispanic decedents. https://www.cdc.gov/nchs/data/series/sr_02/sr02_172.pdf.

§§ By 2013 urbanization classification https://www.cdc.gov/nchs/data_access/urban_rural.htm.

¶¶ Analyses were limited to states meeting the following criteria: For states with very good to excellent reporting, ≥90% of drug overdose deaths mention at least one specific drug in 2016, with the change in drug overdose deaths mentions of at least one specific drug differing by <10 percentage points between 2016 and 2017. States with good reporting had 80% to <90% of drug overdose deaths mention of at least one specific drug in 2016, with the change in the percentage of drug overdose deaths mentioning at least one specific drug differing by <10 percentage points between 2016 and 2017. States included also were required to have stable rate estimates, based on ≥20 deaths, in at least one drug category (i.e., cocaine and psychostimulants with abuse potential) in both 2016 and 2017.

*** Absolute rate change is the difference between 2016 and 2017 rates. Percentage change (i.e., relative change) is the absolute rate change divided by the 2016 rate, multiplied by 100. Nonoverlapping confidence intervals based on the gamma method were used if the number of deaths was <100 in 2016 or 2017, and z-tests were used if the number of deaths was ≥100 in both 2016 and 2017. Note that the method of comparing confidence intervals is a conservative method for statistical significance; caution should be observed when interpreting a nonsignificant difference when the lower and upper limits being compared overlap only slightly. Confidence intervals for 2016 and 2017 rates of cocaine-involved deaths for Asian/Pacific Islanders overlapped only slightly: (0.35–0.54), (0.53–0.76) Confidence intervals of 2016 and 2017 rates of deaths involving psychostimulants with abuse potential for Virginia overlapped only slightly: (0.71–1.13), (1.10–1.60).

††† Statistically significant (p-value <0.05).

§§§ Data with <10 deaths are not reported. Rates based on <20 deaths are not considered reliable and not reported.