Table 1.

Dissociation constants (K_D ± SEM in µM) and selectivities of 1a–n and references methyl β-D-galactopyranoside (11) and methyl β-lactoside (12) binding to galectin-1 and -3 determined in a competitive fluorescence polarization assay [33].

	Galectin-		Selectivity
	1	3	Galectin-1/3
1a	600 ± 48	870 ± 37	1.5
1b	170 ± 2	710 ± 36	4.2
1c	1200 ± 120	720 ± 64	0.6
1d	390 ± 38	500 ± 23	1.3
1e	860 ± 150	610 ± 160	0.7
1f	1100 ± 43	790 ± 48	0.7
1g	1100 ± 16	490 ± 55	0.4
1h	1000 ± 130	>3000	>3
1i	990 ± 23	>3000	>3
1j	500 ± 59	700 ± 52	1.4
1k	240 ± 61	830 ± 38	3.5
1l	180 ± 20	470 ± 95	2.6
1m	710 ± 12	1200 ± 11	1.7
1n	1500 ± 290	1700 ± 190	1.1
11 [35]	>10000	4400	0.4
12 [35]	190	220	1.2