Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Bioessays. 2019 May;41(5):e1900009. doi: 10.1002/bies.201900009

Figure 2.

Figure 2.

MAF1 is a negative regulator of Pol III-mediated transcription of tRNA genes. Under normal growth conditions, mTORC1 mediated phosphorylation of MAF1 prevents its binding to with Pol III. This ensures optimal transcription of tRNA genes to meet cellular metabolic needs. Decreased activity of mTORC1 under conditions of stress leads to decreased phosphorylation of MAF1 thereby promoting its association with Pol III. This results in differential transcription of tRNA genes that alters the cellular tRNA pool to favor translation of stress-responsive proteins.