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. Author manuscript; available in PMC: 2019 May 29.
Published in final edited form as: Schizophr Res. 2016 Dec 27;185:58–66. doi: 10.1016/j.schres.2016.12.017

Fig. 3.

Fig. 3.

Workflow of analysis to identify differentially expressed genes bymoderated t-statistic, and their associated pathways.We again analyzed differentially expressed genes (DEGs) in response to clozapine vs. other atypical antipsychotics in the four studies by our systematic review: Chen et al. (in premotor cortex, PMC), Pietersen et al. (superior temporal gyrus, STG), Mudge et al. (cerebellar cortex, CC), and I wamoto et al. (prefrontal cortex, PFC). For each study, we ranked the DEGs by moderated t-statistic, and selected the top 10 percentile of upregulated genes and the top 10 percentile of downregulated genes.We also performed Ingenuity pathway analysis (IPA) on these genes and identified canonical pathways with p-value <0.05.