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. Author manuscript; available in PMC: 2019 Oct 17.
Published in final edited form as: Sci Transl Med. 2019 Apr 17;11(488):eaav0936. doi: 10.1126/scitranslmed.aav0936

Figure 2. Residual and regrown tumors cannot be eliminated by continued chemotherapy treatment.

Figure 2.

A. To model the schedule of AC treatments administered to patients, AC was administered to mice in regular 21-day intervals (arrows). To enable prolonged dosing without toxic side effects, we used NRG mice for these long-term treatment studies. The horizontal dotted line denotes 100% of the starting tumor volume (measured on day 0). Data shown are mean +/− SEM (n=4 per group).

B. NOD/SCID mice were treated with AC on day 0 and were only re-dosed with AC when tumors regrew to the starting tumor size (arrows). Data shown are mean +/− SEM.

C. NRG mice bearing PIM001-P tumors were treated with a total of 5 cycles of AC, and each subsequent dose was administered only when tumors re-grew to the starting tumor size (arrows). Data shown are mean +/− SEM.