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. Author manuscript; available in PMC: 2019 Oct 17.
Published in final edited form as: Sci Transl Med. 2019 Apr 17;11(488):eaav0936. doi: 10.1126/scitranslmed.aav0936

Figure 3. Residual tumors adopt a distinct histologic state that is reverted in regrown tumors.

Figure 3.

A. Replicate FFPE tumor samples were assembled into TMAs (triplicate 1 mm punches), and stained with H&E.

B. FFPE primary tumor samples obtained from a TNBC patient (ART-57) before, during, and after completion of NACT were stained with H&E and imaged. An image of her metastatic relapse to the chest wall is shown in the bottom panel. Chemotherapy effects on fibrosis and tumor cell morphology are shown with arrows. PaCT, panitumumab + carboplatin + paclitaxel (Taxol). RCB, residual cancer burden assessed by examination of the surgical biopsy. No tx, no treatment was administered between surgery and metastatic relapse. Volumetric reduction after AC treatment was assessed by ultrasound.

Scale bars are 200 µm for parts A&B.