Table 3.
Interaction of prenatal depression group and placental HSD11B2 methylation for baseline cortisol at one month for the overall sample (n=94) and stratified by daughters (n=42) and sons (n=52).1
All |
Daughters |
Sons |
|||||||
---|---|---|---|---|---|---|---|---|---|
Predictor variables | B | SE | p | β | SE | p | β | SE | p |
Baseline Cortisol2 | |||||||||
Intercept | .78 | .64 | .22 | 1.87 | .77 | .02 | .23 | 1.00 | .82 |
Time since feeding (min)2 | −.27 | .10 | .01 | −.64 | .15 | <.001 | −.08 | .14 | .58 |
Education3 | −.53 | .18 | .003 | −.64 | .26 | .02 | −.53 | .24 | .03 |
Control vs. Prenatal MDD4 | −1.80 | .73 | .02 | −2.58 | .89 | .006 | −1.09 | 1.20 | .37 |
Preconception-only MDD vs. Prenatal MDD4 | −1.45 | .80 | .07 | −1.39 | .89 | .13 | −.92 | 1.37 | .51 |
HSD11B2 Methylation | −.08 | .04 | .02 | −.05 | .04 | .21 | −.10 | .06 | .09 |
[Control vs. Prenatal MDD4] * HSD11B2 | .13 | .05 | .02 | .16 | .06 | .01 | .08 | .09 | .38 |
[Preconception vs. Prenatal MDD4] * HSD11B2 | .10 | .06 | .10 | .07 | .07 | .35 | .08 | .10 | .43 |
Per group cell sizes for the overall sample were n’s=43, 21, 30 for Prenatal MDD, Preconception-only MDD, and Control, respectively; per group cell sizes for daughters were n’s=16, 10, and 16, respectively; per group cell sizes for sons were n’s=27, 11, and 14. Unstandardized regression coefficients are presented.
Natural log transformed.
≤ high school degree vs. > high school degree.
MDD=major depressive disorder; contrasts are based on categorical MDD groups.