. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Best Pract Res Clin Haematol. 2019 Feb 7;32(1):74–88. doi: 10.1016/j.beha.2019.02.002

Table 2.

Rheumatoid arthritis and AML risk

Ref	No. of patients	Malignancy type	Cases	Calculated risk (95% CI)
Askling et al(131)	Early arthritis=3703	leukemias	AML = 4 CML = 0	SIR 4.3 (1.2-10.9) SIR 0.0 (0.0-17.7)
	Advanced RA=53067		AML = 68 CML = 13	SIR 2.4 (1.9-3.0) SIR 2.4 (1.3-4.1)
	TNF blockers=4160		AML = 68 CML = 13	SIR 0.0 (0.0-7.4) SIR 2.4 (0.0-27.0)
Hemminki et al(132)	42262 patients followed over 25 years	leukemias	AML = 52	For AML, SIR 2.4 (1.79-3.15) 2000-04: SIR 6.90 (95% CI 2.95-13.66) 1990–99: SIR 2.51 (95% CI 1.14-4.80)