Figure 3. Time to LMD, overall survival, and survival from LMD in patients with glioblastoma diagnosed with LMD at recurrence.
(A) Median time from glioma diagnosis was 11.9 (range 0.9–92.6) months for glioblastoma, 19.1 (1.4–202.8) months for astrocytoma, and 61.7 (3.9–274.8) months for oligodendroglioma (p < 0.0001). Median survival (B) from glioma diagnosis was 17.1 (range 3.1–99) months for glioblastoma, 33.5 (1.5–207) months for astrocytoma, and 132 (8.5–279) months for oligodendroglioma (p < 0.0001). (C) Median survival after LMD diagnosis was 3.8 (range 0.1–32.6) months for glioblastoma, 6.5 (0.1–28.5) months for astrocytoma, and 10.8 (1.8–67.7) months for oligodendroglioma (p = 0.0004). LMD = leptomeningeal disease.