Fig. 5.

Timeline of events coordinating repair. Injured cells undergo a set of overlapping events that occur in a sequential manner to enable successful membrane repair. The membrane repair process includes events required to reseal the wounded membrane, as well as the cytoskeletal reassembly and other events required to return the cell membrane to its pre-injury state. The events involved in the repair response do not have a discreet start and stop time as they depend on the nature of injury and the cell type involved in the repair response. However, these steps proceed in a stereotypical order illustrated here, which ensures rapid (< 5 min) repair of plasma membrane injury. Similar stereotypical events can occur at a slower (minutes to hours) timescale in the injured and surrounding cells to potentiate repair from a subsequent membrane injury, as well as repair of damage to the tissue caused by single cell injury. The details of these events are discussed in the text